Description: A hands-on, design-forward introduction to experimental
chemical biology for students new to the field. Organized around two modern
modules—(1) glucose sensing with DNA aptamers and (2) CRISPR/Cas12a-based viral
nucleic-acid detection—the course builds core laboratory competencies and emphasizes
experimental design: students formulate hypotheses, select assay parameters and justify
controls to meet performance targets (specificity, sensitivity, dynamic range). Work
proceeds through approximately 12 scaffolded experiments that incorporate guided
choice points, iteration, and quantitative decision-making. Emphasis is placed on safety,
reproducibility, and interpreting assay performance (specificity, sensitivity, dynamic
range). Instruments include a microplate reader, PAGE system, DNA spin-purification
columns, a NanoDrop, and micropipettes. Open to undergraduate students only. No prior
experience in chemical biology is required; recommended background includes general
chemistry with laboratory and organic chemistry laboratory (or permission of the
instructor). Two credit hours.