BIOE 490 - INTRO SYSTEMS BIOLOGY MODELING
Long Title: INTRO COMPUTATIONAL SYSTEMS BIOLOGY: MODELING & DESIGN PRINCIPLES OF BIOCHEM NETWORKS
Grade Mode: Standard Letter
Course Type: Lecture
Credit Hours: 3
Must be enrolled in one of the following Level(s):
Prerequisite(s): (MATH 212 OR MATH 213) AND (BIOE 252 OR CHBE 310) AND BIOC 341 AND CAAM 210
Description: The course summarizes techniques for quantitative analysis and simulations of basic circuits in genetic regulation, signal transduction and metabolism. We discuss engineering approaches adapted to computational systems biology and aim to formulate evolutionary design principles explaining organization of networks in terms of their physiological demands. We discuss biochemical simulation methodology and software as well as recent advances in the field. Topics include end-product inhibition in biosynthesis, optimality and robustness of the signaling networks and kinetic proofreading. Graduate/Undergraduate Equivalency: BIOE 552. Mutually Exclusive: Cannot register for BIOE 490 if student has credit for BIOE 552.