BIOE 515 - ENGINEERING DRUG DELIVERY SYS.
Long Title: ENGINEERING DRUG DELIVERY SYSTEMS
Grade Mode: Standard Letter
Course Type: Lecture
Credit Hours: 3
Must be enrolled in one of the following Level(s):
Description: This course will focus on the application of innovative engineering approaches to enhance drug efficacy and/or reduce toxicity. Topics of emphasis include, but are not limited to, routes of administration, bioavailability, biodistribution, pharmacokinetics, pharmacodynamics, therapeutic drug windows, patient compliance, immunogenicity, the foreign body reaction, and solubility enhancement. A wide array of device types will be discussed, such as biodegradable microspheres, self-assembled lipid nanoparticles, microneedles, and osmotic pumps. Students will be expected to quantitatively evaluate drug release from complex devices and determine drug distribution and clearance using multi-compartment models. An additional project will be required of graduate level students.