Course Schedule and Catalog

Long Title: MOLECULAR BIOPHYSICS I

Department: Biochemistry and Cell Biology

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): (BIOS 301 OR BIOC 301) AND (BIOS 352 OR BIOC 352) or permission of instructor

Description: Focus on principles of common biophysical methods used for study of conformations and dynamics of biological macromolecules and assemblies. Topics cover spectroscopic methods (absorption, fluorescence, circular dichroism, epr, NMR), transport processes, sedimentation, calorimetry, mass spectrometry, crystallography, cryo-electron microscopy, atomic force microscopy, ligand-protein interactions, protein folding, single molecule detection, computer simulations, functional genomics and laboratory evolution. Biological examples will be used to demonstrate merits and complementarity in each of the biophysical methods. Graduate/Undergraduate Equivalency: BIOC 551.