Course Schedule and Catalog

Long Title: FRESHMAN SEMINAR IN BIONANOTECHNOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Distribution Group: Distribution Group III

Credit Hours: 3

Description: This seminar course is intended for freshman and will provide an introduction to bionanotechnology. In addition to learning about cutting-edge research in bionanotechnology, students will work to formulate solutions to medical problems using the tools of nanotechnology.

Long Title: ADVANCES IN BIOENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hours: 1

Description: This seminar is suitable for freshman, sophomores, and non-majors. A series of guest lectures will introduce students to cutting-edge advances in bioengineering. Repeatable for Credit.

Long Title: PHILOSOPHICAL CHALLENGES AND ENGINEERING APPLICATIONS OF STEM CELLS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Distribution Group: Distribution Group III

Credit Hours: 3

Description: The course integrates philosophy and bioengineering approaches to stem cells. Students will learn the basic concepts and foundational values of stem cell biology, alongside biological mechanisms and engineering applications. Cross-list: PHIL 204.

Long Title: BIOENGINEERING FUNDAMENTALS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): MATH 101 AND MATH 102 AND CHEM 122 AND CAAM 210 AND (PHYS 101 OR PHYS 125 OR PHYS 111) AND (PHYS 102 OR PHYS 126 OR PHYS 112)

Description: Introduction to material, energy, charge, and momentum balances in biological systems. Steady state and transient conservation equations for mass, energy, charge and momentum will be derived and applied using basic mathematical principles, physical laws, stoichiometry, and thermodynamic properties. Problem based learning groups will solve open-ended problems. Students will register for sections during the first week of classes. Required for students intending to major in bioengineering. Recommended co or prerequisite(s): MATH 211.

Long Title: ACCELERATED CELL AND MOLECULAR BIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): CHEM 121

Description: This course is intended for engineers and physical scientists who want to have a working knowledge of modern cell and molecular biology. Key concepts will be illustrated through examples in biotechnology and biomedicine. Prior coursework in biology is not required.

Long Title: SYSTEMS BIOLOGY OF BLOOD VESSELS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: How blood vessels respond to hypoxia is a process critical to the progression of many diseases and conditions including cardiovascular disease, cancer, cerebrovascular disease, diabetes, obesity and arthritis. Physiological processes such as exercise, aging, and wound healing also depend on hypoxia-induced microvessel changes. This course introduces concepts of hypoxic response, angiogenesis, and capillary remodeling - from the effects at the intracellular level to the whole body. Topics covered include computational systems biology modeling of hypoxia and angiogenesis, the use of angiogenesis in tissue engineering and regenerative medicine, imaging of blood vessel dynamics, capillaries of the brain, and the design of new blood vessels. Graduate/Undergraduate Equivalency: BIOE 507. Mutually Exclusive: Cannot register for BIOE 307 if student has credit for BIOE 507.

Long Title: SYSTEMS PHYSIOLOGY LAB MODULE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 1

Prerequisite(s): BIOE 252 AND (BIOS 332 OR BIOE 322 OR BIOC 332)

Description: Exploration of physiologic systems through measurement of biologic signals. EEG, ECG, EMG pulmonary function tests, etc. are performed and analyzed. Students will explore physiologic concepts through computer simulations, data collection, and analysis. Enrollment in or completion of BIOE 322 is expected and maybe taken the same semester as BIOE 320. For students intending to major in Bioengineering. Instructor Permission Required.

Long Title: CELLULAR ENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 252 or permission of instructor

Description: Introduction to engineering principles and modeling regulation and circuitry at the cellular level. Topics include genetic metabolic networks and cell surface interactions.

Long Title: FUNDAMENTALS OF SYSTEMS PHYSIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): (BIOE 252 OR BIOC 201 OR BIOS 201) AND (MATH 211 OR MATH 213)

Description: This course will teach the fundamentals of human physiology from an engineering perspective, with specific focus on the nervous, cardiovascular, respiratory and urinary systems. Lectures, assignments and exams will be quantitative and will introduce engineering principles, such as conservation of mass and energy, controls and system analysis, thermodynamics and mass transport, and apply them to the study of physiologic systems. Cross-list: BIOC 332.

Long Title: BIOREACTION ENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 252 AND (BIOC 201 OR BIOS 201)

Description: Application of engineering principles to biological processes. Mathematical and experimental techniques for quantitative descriptions of enzyme kinetics, metabolic and genetic networks, cell growth kinetics, bioreactor design and operation.

Long Title: BIOENGINEERING THERMODYNAMICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 252 AND MATH 212 or permission of instructor

Description: This course will be a mathematically rigorous and quantitative coverage of the fundamentals of thermodynamics with applications drawn from contemporary bioengineering problems. Fundamental topics will include the First and Second Law, Entropy Inequality, Biggs and Helmholtz Free Energy, Maxwell Relations, Chemical Potential, Equilibrium, Phase Transitions, Solution Thermodynamics, Electrochemistry and Statistical Mechanics. Advanced topics will include self-assembly, the hydrophobic effect, interfacial phenomena, polymer and membrane phase transitions, membrane transport, electromechanically coupling and on-equilibrium thermodynamics. The course ill cover the role that thermodynamics plays in molecular engineering and the design of biologically-inspired materials.

Long Title: LABORATORY IN TISSUE CULTURE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 1

Prerequisite(s): BIOE 440 OR STAT 440 OR BIOC 311 OR BIOS 311

Description: Introduction to tissue culture techniques, including cell passage, cell viability, and cell attachment and proliferation assays. Graduates complete quantitative analysis of their data. Engineering design and applications are featured in graded work. Sections 1 and 2 are taught during the first half of the semester. Sections 3 and 4 are taught during the second half of the semester. Students may be required to attend lab on a university holiday. Your registration for this course will not be accepted until you obtain Dr. Saterbak's signature on an Undergraduate Special Registration Request form. Instructor Permission Required.Cross-list: BIOC 320.

Long Title: APPROPRIATE DESIGN FOR GLOBAL HEALTH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Distribution Group: Distribution Group III

Credit Hours: 3

Prerequisite(s): GLHT 201

Description: Seminar-style introductory design course covering epidemiology, pathophysiology, health systems, health economics, medical ethics, humanitarian emergencies, scientific and engineering design methods, and appropriate health technology case studies. To register, you must be enrolled in the GLHT minor and submit a 250 statement to beyondtraditionalborders@rice.edu by Monday of preregistration. The minor and course prerequisite is waived for students majoring in Bioengineering. Instructor Permission Required.Cross-list: GLHT 360.

Long Title: METABOLIC ENGINEERING FOR GLOBAL HEALTH ENVIRONMENTS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): (BIOE 362 OR GLHT 362) AND (PHYS 126 OR PHYS 102 OR PHYS 112 OR PHYS 142) AND MATH 102

Description: Importance of nutritional and pharmaceutical compounds, impact of cost of compounds on global health; overview of biochemical pathways; Genetic engineering and molecular biology tools for ME; Nutritional molecules; Pharmaceuticals (antibiotics, tamiflu-against influenza virus; anti-parasite compounds against malaria and filarial diseases; anti-diarrhea treatments). Cross-list: BIOC 361, GLHT 361.

Long Title: SUSTAINABLE WATER PURIFICATION FOR THE DEVELOPING WORLD

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 1

Description: This course is an introduction to several innovative methods of small-scale water purification which are appropriate for implementation in the developing world. Through the different components of the course, students will acquire and hone a sustainable methodology for addressing global health problems at the local level. Cross-list: CEVE 314.

Long Title: BIOMATERIALS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 252 AND CHEM 211 AND (MECH 211 OR CEVE 211) or permission of instructor

Description: This course will introduce both basic materials science and biological concepts with an emphasis on application of basic quantitative engineering principles to understanding the interactions between materials and biological systems. Topics covered include chemical structure of biomaterials, physical, mechanical, and surface properties of biomaterials, biomaterial degradation, and biomaterial processing. Additional topics include protein and cell interactions with biomaterials, biomaterial implantation, and acute inflammation, wound healing and the presence of biomaterials immune responses to biomaterials, biomaterials, immune responses to biomaterials, biomaterials and thrombosis, as well as infection, tumorigenesis, and calcification of biomaterials that can collectively apply to design of biomaterials for myriad applications. MECH 211 or CEVE 211 may be taken concurrently with BIOE 370.

Long Title: BIOMECHANICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 252 AND MATH 212 AND (MECH 211 OR CEVE 211) or permission of instructor

Description: This course introduces the fundamental principles of mechanics applied to the analysis and characterization of biological systems. Topics covered include normal and shear stresses, normal and shear strains, mechanical properties of materials, load, deformation, elasticity and elastoplastic behavior. Quantitative analysis of statically determinate and indeterminate structures subjected to tension, compression, torsion and bending will be covered. Additionally, aspects of blood rheology, viscoelasticity, and musculoskeletal mechanics will be addressed.

Long Title: FUNDAMENTALS OF ELECTROPHYSIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: An introduction to cellular electrophysiology. Includes development of whole-cell models for neurons and muscle (cardiac and skeletal muscle) cells, based on ion channel currents obtained from whole-cell voltage-clamp experiments. Material balance equations are developed for various ions and chemical signaling agents (e.g., second messengers). numerical methods are introduced for solving the ordinary and partial differential equations associated with these models. Several types of cell models are discussed ranging from neurons and muscle cells to sensory cells of mechanoreceptors, auditory hair cells and photoreceptor cells. Volume conductor boundary-value problems frequently encountered in electrophysiology are posed. Course provides a cellular basis fo the interpretation of macroscopic bioelectric signals such as the electrocardiogram (ECG), electromyogram (EMG), electroretinogram (ERG) and electroencephalogram (EEG). Requirements: Knowledge of ordinary differential equations, electrical circuits and electromagnetic field theory in elementary physics. Cross-list: ELEC 381.

Long Title: BIOMEDICAL ENGINEERING INSTRUMENTATION

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): MATH 211 AND ELEC 243 AND (BIOC 201 OR BIOS 201) AND (PHYS 102 OR PHYS 126 OR PHYS 112)

Description: This is an introductory level course on fundamentals of biomedical engineering instrumentation and analysis. Topics include measurement principles; fundamental concepts in electronics including circuit analysis, data acquisition, amplifiers, filters and A/D converters; Fourier analysis; temperature, pressure, and flow measurements in biological systems.

Long Title: BIOMEDICAL INSTRUMENTATION LAB

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 1

Description: Students will gain hands on experience with building biomedical instrumentation circuits and systems. Students will learn the basics of lab view programming and signal analysis. Preregistration for sections is required during registration week. Instructor Permission Required.

Long Title: NUMERICAL METHODS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 252 AND CAAM 210 AND MATH 211 AND MATH 212

Description: Introduction to numerical approximation techniques with bioengineering applications. Topics include error propagation, Taylor's Series expansions curre fitting, roots of equations, optimization numerical differentiation and integration, ordinary differential equations, and partial differential equations. Matlab and other software will be used for solving equations. Math 212 may be taken concurently as BIOE 391.

Long Title: ENGINEERING UNDERGRADUATE RESEARCH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Research

Credit Hours: 1 TO 4

Description: Independent investigation of a specific topic or problem in modern bioengineering research under the direction of a selected faculty member. Research project has a strong engineering component. Repeatable for Credit.

Long Title: UNDERGRADUATE RESEARCH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Research

Credit Hours: 1 TO 4

Description: Independent investigation of a specific topic or problem in modern bioengineering research under the direction of a selected faculty member. Repeatable for Credit.

Long Title: SUMMER UNDERGRADUATE RESEARCH

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 1 TO 4

Description: Independent investigation of a specific topic or problem in modern bioengineering research under the direction of a selected faculty member. Instructor Permission Required. Repeatable for Credit.

Long Title: ADVANCES IN BIONANOTECHNOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hours: 3

Prerequisite(s): BIOE 370

Description: This course covers nanotechnology applications in bioengineering. Students learn about cutting edge research that uses the tools of nanotechnology to tackle medical problems. Topics include bionanotechnology - related research for diagnosis, detection, and treatment of disease; cell targeting; drug design and delivery; gene therapy; prostheses and implants and tissue regeneration. (REGISTRATION NOTE: The prerequisite BIOE 370 can also be taken concurrently with BIOE 403)

Long Title: INDEPENDENT RESEARCH/INTERNSHIP PROGRAM

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Independent Study

Credit Hours: 0

Description: This independent research course offers multi-disciplinary training in the area of cellular engineering within the Departments of Bioengineering and Biochemistry & Cell Biology. Areas of research will include engineering of hard and soft tissue formation, cardiovascular tissue engineering, engineering cell surface interactions regulating movement and metabolic engineering. Students will conduct independent research under the supervision of a faculty mentor. Instructor Permission Required.

Long Title: CLINICAL MEDICAL INTERNSHIP

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Independent Study

Credit Hours: 3

Description: Students participate in clinical inpatient rounds, outpatient visits, operating room procedures and medical grand rounds. Designed to provide direct contact with the medical needs addressed by bioengineering. Instructor Permission Required.

Long Title: CLINICAL RESEARCH INTERNSHIP

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Independent Study

Credit Hours: 3

Description: Students participate in clinical inpatient rounds, outpatient visits, operating room procedures and medical grand rounds. Designed to provide direct contact with the medical needs addressed by bioengineering. Instructor Permission Required.

Long Title: BIOSYSTEMS TRANSPORT AND REACTION PROCESSES

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): MATH 211 AND MATH 212 AND (BIOE 332 OR CHBE 411)

Description: The principles of transport phenomena and reaction kinetics will be used to quantitatively describe biological systems. Thermodynamics will be reviewed for the study of fluid and mass transport. The basic equations that describe convection, diffusion, and reaction will be derived. Membrane, metabolite, and oxygen transport will be covered in detail. Basic aspects of pharmacokinetics and reactor design will be discussed. Models of normal, abnormal, and bioartificial organ function will be developed. Cross-list: CHBE 420.

Long Title: GENE THERAPY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 3

Prerequisite(s): CHEM 212 AND (BIOS 201 OR BIOC 201) or permission of instructor

Description: This course will examine the gene therapy field, with topics ranging from gene delivery to vectors to ethics of gene therapy. The design principles for engineering improved gene delivery vectors, both viral and nonviral, will be discussed. The course will culminate in a design project focused on engineering a gene delivery device for a specific therapeutic application. Graduate/Undergraduate Equivalency: BIOE 522. Mutually Exclusive: Cannot register for BIOE 422 if student has credit for BIOE 522.

Long Title: PHARMACEUTICAL ENGINEERING AND DRUG DELIVERY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 391 or permission of instructor

Description: The course introduces the principles of pharmaceutical design, development and delivery. Topics include drug administration, transport, and the pharmacokinetics of distribution in the human body. We will also cover the use of polymeric biomaterials in the development of controlled delivery devices and discuss manufacturing and regulatory implications of such products.

Long Title: BIOMATERIALS ENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): (CHEM 211 OR CHEM 251) AND (BIOS 201 OR BIOC 201) AND BIOE 370 or permission of instructor

Description: Emphasis will be placed on issues regarding design and synthesis of materials to achieve specific properties and biocompatibility. An overview of significant biomaterials application will be given, including topics such as ophthalmic biomaterials, orthopedic applications, cardiovascular biomaterials, and drug delivery systems. Regulatory issues concerning biomaterials will also be addressed. Graduate/Undergraduate Equivalency: BIOE 631. Mutually Exclusive: Cannot register for BIOE 431 if student has credit for BIOE 631.

Long Title: BIOFLUIDS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: This course provides an introduction to the basic principles of fluid mechanics, emphasizing their importance in the study of biological systems. The course will cover fluid properties, hydrostatics, boundary layers, flow in pipes, laminar and turbulent flows and other fundamental concepts with biomedical applications.

Long Title: STATISTICS FOR BIOENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 1

Prerequisite(s): BIOE 252

Description: Course covers application of statistics to bioengineering. Topics include descriptive statistics, estimation, hypothesis testing, ANOVA, and regression. Offered first five weeks of the semester. BIOE 252 may be taken concurrently with BIOE 440. Cross-list: STAT 440.

Long Title: TISSUE ENGINEERING LAB MODULE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 1

Prerequisite(s): (BIOE 342 OR BIOC 320 OR BIOS 320) AND (BIOE 440 OR STAT 440)

Description: Students design and conduct a series of tests to synthesize PLLA, characterize PLLA and PLGA, monitor PLLA and PLGA degradation, and assess the viability, attachment, and proliferation of HDF cells on PLLA films. The experiments include many of the basic types of experiments that would be required to do a preliminary investigation of a tissue engineered product. Sections 1 and 2 will be taught during the first half of the semester and sections 3 and 4 will be taught during the second half of the semester. In addition sections 1 and 3 will need to come into lab on 2-3 Fridays and sections 2 and 4 will need to come into lab on 2-3 Saturdays. Section sign-up is required by the instructor in Keck 108 during preregistration week.

Long Title: BIOPROCESSING LAB MODULE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 1

Prerequisite(s): (BIOE 342 OR BIOC 320 OR BIOS 320) AND (BIOE 440 OR STAT 440)

Description: Students design and conduct a series of experiments to observe the growth of E. coli under different conditions, including agar plates, shake flasks, and a small-scale bioreactor. The E. coli has been transformed with a plasmid that produces beta-galactosidase. Engineering applications are emphasized. Some work "off hours" (early evening) is required. Sections 1 and 2 are taught in the first half of the semester and Sections 3 and 4 are taught in the second half of the semester. Section sign-up is required by the instructor in Keck 108 during preregistration week.

Long Title: MECHANICAL TESTING LAB MODULE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 1

Prerequisite(s): BIOE 372 AND (BIOE 440 OR STAT 440)

Description: Students design and conduct a series of tests to elucidate the mechanical and material properties of animal tissue using the Instron. Section sign-up is required by the instructor in Keck 108 during the preregistration week. BIOE 372 may be taken concurrently with BIOE 444. Instructor Permission Required.

Long Title: ADVANCED INSTRUMENTATION LAB MODULE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Laboratory

Credit Hours: 1

Prerequisite(s): BIOE 383 AND BIOE 385 AND (BIOE 440 OR STAT 440)

Description: Students design and build a biomedical instrumentation device. Sign up is required in Keck 108 during preregistration week.

Long Title: COMPUTATIONAL MODELING LAB

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture/Laboratory

Credit Hours: 1

Prerequisite(s): BIOE 391

Description: This course offers a hands-on application to systems biology modeling. Students will learn a range of modeling methods, and apply them directly in class to current bioengineering problems. Weekly tutorials will be offered, and a laptop is required (or can be loaned). Topics covered include in silico drug delivery and design studies, integrating multiscale models with high-resolution imaging, experimental design vial computer modeling, and patient-specific simulations. Modeling methods include protein-protein interaction networks, biocircuits, stochastic differential equations, agent-based modeling, computational fluid dynamics, and finite element modeling.

Long Title: BIOENGINEERING DESIGN I

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 383 AND BIOE 385 AND (BIOE 332 OR BIOE 372)

Description: Senior Bioengineering students will design devices in biotechnology or biomedicine. This project-based course covers systematic design processes, engineering economics, FDA requirements, safety, engineering ethics, design failures, research design, intellectual property rights, environmental impact, business planning and marketing. Students will be expected to compile concise documentation and present orally progress of their teams. It is required that students take both parts of this course in the same year. BIOE 451 and 452 must be taken the same academic year. Instructor Permission Required.

Long Title: BIOENGINEERING DESIGN II

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 451

Description: Senior Bioengineering students will design devices in biotechnology or biomedicine. This project-based course covers systematic design processes, engineering economics, FDA requirements, safety, engineering ethics, design failures, research design, intellectual property rights, environmental impact, business planning and marketing. Students will be expected to compile concise documentation and present orally progress of their teams. It is required that students take both parts of this course in the same school year. BIOE 451 and 452 must be taken the same academic year. Instructor Permission Required.

Long Title: COMPUTATIONAL FLUID MECHANICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Fundamental concepts of finite element methods in fluid mechanics, including spatial discretization and numerical integration in multidimensions, time-integration, and solution of nonlinear ordinary differential equation systems. Advanced numerical stabilization techniques designed for fluid mechanics problems. Strategies for solution of complex, real-world problems. Topics in large-scale computing, parallel processing, and visualization. Cross-list: CEVE 454, MECH 454, Graduate/Undergraduate Equivalency: BIOE 554. Mutually Exclusive: Cannot register for BIOE 454 if student has credit for BIOE 554.

Long Title: SYSTEMS BIOLOGY AND MOLECULAR DESIGN

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: This course portends to give a balanced view of current developments in integrative biology that may lead to future design concepts for the molecular therapy of malignancy.

Long Title: EXTRACELLULAR MATRIX

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOS 341 OR BIOC 341

Description: This course will address the biology, organization, mechanics, and turnover of extracellular matrix. There will be an emphasis on cells and cell-matrix interactions, matrix distributions in connective tissues and organs, techniques for measurement and modeling, changes with growth and aging, and tissue/matrix degradation. Cross-list: BIOC 464. Recommended Prerequisite(s): BIOE 372, BIOC 341.

Long Title: FROM SEQUENCE TO STRUCTURE: AN INTRODUCTION TO COMPUTATIONAL BIOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 4

Description: Contemporary introduction to problems in computational biology spanning sequence to structure. The course has three modules: the first introduces students to the design and statistical analysis of gene expression studies; the second covers statistical machine learning techniques for understanding experimental data generated in computational biology; and the third introduces problems in the modeling of protein structure using computational methods from robotics. The course is project oriented with an emphasis on computation and problem-solving. Cross-list: COMP 470, STAT 470. Recommended Prerequisites: COMP 280 and (STAT 310 or STAT 331).

Long Title: COMPUTATIONAL NEUROSCIENCE

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Introduction to anatomy and physiology and of the brain, basic electrophysiology, development of models of neurons and natural neural networks. Includes descriptions of neuromorphic circuits, which can represent neuron and network behavior in silicon. Course serves as an introduction to Neural Engineering. Requirements: Knowledge of basic electrical and operational amplifier circuits; and ordinary differential equations. Cross-list: ELEC 481, NEUR 481.

Long Title: PHYSIOLOGICAL CONTROL SYSTEMS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 4

Description: A study of the somatica nd autononmic nervous system control of biological systems. Simulation methods, as well as, techniques common to linear and nonlinear control theory are used. Also included is an introduction to sensors and instrumentation techniques. Examples are taken from the cardiovascular, respiratory, and visual systems. Requirements: Knowledge of basic electrical and operational amplifier circuits; and ordinary differential equations. Cross-list: ELEC 482.

Long Title: INTRODUCTION OF BIOMEDICAL INSTRUMENT AND MEASUREMENT TECHNIQUES

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Review of basic sensors and measurement principles. Includes design problems using operational amplifier circuits (e.g., instrumentation and isolation amplifiers, comparators, timer circuits). Introduction to development of virtual instruments (VIs) using LabView. Discussion of micro-and macro-biopotential electrodes, cell cytometry, the measurement of blood pressure, blood flow, and heart sounds, temperature, and the principles of electrical safety (e.g., micro- and macro-shock hazards in the clinical environment). Includes discussion of pulmonary instrumentation and medical applications of ultrasound. Two lab exercises and a term project required. Cross-list: ELEC 483, MECH 483.

Long Title: BIOPHOTONICS INSTRUMENTATION AND APPLICATIONS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 383 or permission of instructor

Description: Introduction to fundamentals of biophotonics instrumentation related to coherent light generation, transmission by optical componenets such as lenses and fibers, and moduation and detection. Interference and polarization concepts and light theories including ray and wave optics will be covered. Biomedical applications in optical sensing and diagnosis will be discussed.

Long Title: FUNDAMENTALS OF MEDICAL IMAGING I

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: This course will introduce basic principles of image acquisition, formation and processing of several medical imaging modalities such as X-Ray, CT, MRI, and US that are used to evaluate the human anatomy. The course also includes visits to a clinical site to gain experience with the various imaging modalities covered in class. Cross-list: COMP 485, ELEC 485, Graduate/Undergraduate Equivalency: BIOE 685. Recommended Prerequisite(s): MATH 211 and MATH 212.

Long Title: FUNDAMENTALS OF MEDICAL IMAGING II

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): ELEC 485 OR BIOE 485 OR COMP 485

Description: This course focuses on functional imaging modalities used specifically in nuclear medicine such as Gamma cameras, SPECT, and PET imaging. The course will introduce the basic principles of image acquisition, formation, processing and the clinical applications of these imaging modalities and lays the foundations for understanding the principles of radiotracer kinetic modeling. A trip to a clinical site in also planned to gain experience with nuclear medicine imaging. Cross-list: COMP 486, ELEC 486.

Long Title: INTRO COMPUTATIONAL SYSTEMS BIOLOGY: MODELING & DESIGN PRINCIPLES OF BIOCHEM NETWORKS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): MATH 212 OR MATH 213 AND BIOS 341

Description: The course summarizes techniques for quantitative analysis and simulations of basic circuits in genetic regulation, signal transduction and metabolism. We discuss engineering approaches adapted to computational systems biology and aim to formulate evolutionary design principles explaining organization of networks in terms of their physiological demands. We discuss biochemical simulation methodology and software as well as recent advances in the field. Topics include end-product inhibition in biosynthesis, optimality and robustness of the signaling networks and kinetic proofreading. Students are expected to represent several journal articles. Same as 552 but with more emphasis on simulation techniques and problems solving. Graduate/Undergraduate Equivalency: BIOE 552. Mutually Exclusive: Cannot register for BIOE 490 if student has credit for BIOE 552.

Long Title: SENSORY NEUROENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 332 AND BIOE 384 or permission of instructor

Description: This course will explore how bioengineering techniques and principles are applied to understand and model sensory systems, with a focus on the auditory, vestibular, and visual systems. The interaction between the electrical, mechanical and optical aspects of these systems, and ways to modulate these interactions, will be explored. The course will also cover the design of current auditory, visual and somato-sensory neuroprosthetics (i.e. cochlear implants, retinal implants and brain-machine interfaces), as well as emerging technologies for neural stimulation. Graduate/Undergraduate Equivalency: BIOE 592. Mutually Exclusive: Cannot register for BIOE 492 if student has credit for BIOE 592.

Long Title: BIOMEMS AND MEDICAL MICRODEVICES

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Our society is on the cusp of a revolution that will change the practice of medicine. Microfabrication methods that have empowered electronics are now starting to invade areas of biomedical devices. Through this course, students will obtain knowledge of basic element and major classes of molecular sensors, nanodevices, and biomedical Microsystems. NOTE: The graduate version of this course will require more advanced work in the form of exams and presentation than the undergrad version. Cross-list: CHEM 498, Graduate/Undergraduate Equivalency: BIOE 598.

Long Title: GRADUATE RESEARCH

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Research

Credit Hours: 1 TO 15

Description:  Repeatable for Credit.

Long Title: GRADUATE RESEARCH

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Research

Credit Hours: 1 TO 15

Description: Only first semester graduate students are eligible to take this course.

Long Title: GRADUATE INDEPENDENT STUDY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Research

Credit Hours: 0 TO 2

Description: Independent investigation of a specific topic in modern bioengineering research under the direction of selected faculty member. Instructor Permission Required. Repeatable for Credit.

Long Title: OPTICAL IMAGING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: This course includes a theoretical portion which will introduce the fundamentals of optical imaging of neural activity, present the devices that are employed, and review applications and discuss their results. In addition, in a practical part, students will design, set up, and perform simple in vitro experiments to gain practical experience with this exciting and powerful technology. Course meets in S744, Vivian Smith Res. Bldg., Baylor College of Medicine

Long Title: GRADUATE INDEPENDENT STUDY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Research

Credit Hours: .5 TO 3

Description: Independent investigation of a specific topic in modern bioengineering research under the direction of a faculty member. Repeatable for Credit.

Long Title: SYSTEMS BIOLOGY OF BLOOD VESSELS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): MATH 381

Description: How blood vessels respond to hypoxia is a process critical to the progression of many diseases and conditions including cardiovascular disease, cancer, cerebrovascular disease, diabetes, obesity and arthritis. Physiological processes such as exercise, aging, and wound healing also depend on hypoxia-induced microvessel changes. This course introduces concepts of hypoxic response, angiogenesis, and capillary remodeling - from the effects at the intracellular level to the whole body. Topics covered include computational systems biology modeling of hypoxia and angiogenesis, the use of angiogenesis in tissue engineering and regenerative medicine, imaging of blood vessel dynamics, capillaries of the brain, and the design of new blood vessels. Graduate students will be required to complete a term research project and present a related short seminar. Graduate/Undergraduate Equivalency: BIOE 307. Mutually Exclusive: Cannot register for BIOE 507 if student has credit for BIOE 307.

Long Title: OPTICAL IMAGING AND DETECTION FOR BIOENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: The course is a comprehensive introduction to a broad variety of optical imaging and detection techniques with special emphasis on implementation to clinical and biological use. Presented methods include numerous microscopy techniques, spectral imaging, polarimetry, OCT, and others. The course will guide through the principles and concepts used in a variety of optical instruments and point special requirements for bio- medical applications.

Long Title: SYSTEMS BIOLOGY AND MOLECULAR DESIGN

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOS 301 OR BIOS 201 OR BIOS 551 OR CHEM 311 or permission of instructor

Description: The course introduces systems biology concepts and their bearing on molecular design. The course portends to present a balanced and integrative outlook at the various molecular components that determine biological function, sub-cellular organization and dysfunction. The focus is placed on the molecular aspects and design principles governing protein interactivity, supra-molecular organization and interactome modularity. Practical applications will be delineated; in particular those pertaining to the development of systems-based design principles to avert side effects in drug therapy.

Long Title: BIOSYSTEMS TRANSPORT PHENOMENA

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: The principles of transport phenomena will be used to quantitatively describe biological systems. Recommended Pre-requisite: BIOE 322 and graduate standing or permission of instructor.

Long Title: GENE THERAPY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): CHEM 212 AND (BIOS 201 OR BIOC 201) or permission of instructor

Description: This course will examine the gene therapy field, with topics ranging from gene delivery to vectors to ethics of gene therapy. The design principles for engineering improved gene delivery vectors, both viral and nonviral, will be discussed. The course will culminate in a design project focused on engineering a gene delivery device for a specific therapeutic application. Graduate/Undergraduate Equivalency: BIOE 422. Mutually Exclusive: Cannot register for BIOE 522 if student has credit for BIOE 422.

Long Title: INTRODUCTION TO SYSTEMS BIOLOGY AND SYSTEMS BIOTECHNOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Systems biology is an integrated experimental and mathematical approach to study the complex dynamic interactions between various components of a biological system. The course is designed to explore the basic concepts of systems biology. The course will introduce "systems" approaches based on genomics, transcriptomics, proteomics and metabolomics.

Long Title: MACROMOLECULAR SYSTEMS BIOENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Multi-component complexes of biological macromolecules form the basis of many cellular processes including signaling, metabolism, and biomolecular transport. This course will examine the impact of supramolecular architecture on these processes by discussing the self-assembly, dynamic properties and physiological function of non-covalently coupled macromolecules and interacting proteins. The course will cover fundamental models of protein-protein interactions, cooperativity, instrumentation, and potential technological applications.

Long Title: INTRO COMPUTATIONAL SYSTEMS BIOLOGY: MODELING & DESIGN PRINCIPLES OF BIOCHEM NETWORKS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): (MATH 212 OR MATH 213) AND BIOS 314

Description: The course summarizes techniques for quantitative analysis and simulations of basic circuits in genetic regulation, signal transduction and metabolism. We discuss engineering approaches adapted to computational systems biology and aim to formulate evolutionary design principles explaining organization of networks in terms of their physiological demands. We discuss biochemical simulation methodology and software as well as recent advances in the field. Topics include end-product inhibition in biosynthesis, optimality and robustness of the signaling networks and kinetic proofreading. Students are expected to represent several journal articles. Same as 490 but with more emphasis on recent advances in the field - paper reading and presentations. Graduate/Undergraduate Equivalency: BIOE 490. Recommended Prerequisite(s): Basic knowledge of biochemistry, cell biology, linear algebra, and ordinary differential equations is expected. Mutually Exclusive: Cannot register for BIOE 552 if student has credit for BIOE 490.

Long Title: COMPUTATIONAL FLUID MECHANICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Graduate version of BIOE 454. Additional work required. Cross-list: CEVE 554, MECH 554, Graduate/Undergraduate Equivalency: BIOE 454. Mutually Exclusive: Cannot register for BIOE 554 if student has credit for BIOE 454.

Long Title: PRINCIPLES OF BIOENGINEERING I - THEORETICAL PRINCIPLES OF BIOENGINEERING I

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: The goal of this full year course is to develop a firm foundation for and a fundamental knowledge of the field of Bioengineering. The course is split into two semesters, each comprised of several different modules. BIOE 561 (Principles of Bioengineering I) includes Thermodynamics, Statistical mechanics, molecular biophysics, transport and biomaterials. This course may be taken by all first-year graduate students. Both BIOE 561 and BIOE 562 must be taken during the same academic year.

Long Title: PRINCIPLES OF BIOENGINEERING II - TECHNIQUE AND APPLICATIONS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 561

Description: This is the second module of a full year course. The goal is to develop a firm foundation for and a fundamental knowledge of the field of Bioengineering. The course is split into 2 semesters each comprised of several different modules. BIOE 562 (Principles of Bioengineering II) includes systems and signaling, micro-fluidics, nano-optics, miniature optics, microscopy, molecular biology, stem cells, and high through-put screens assays. This course must be taken by all first year graduate students. Both BIOE 561 and 562 must be taken during the same academic year.

Long Title: BIOINFORMATICS: NETWORK ANALYSIS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: This course covers computational aspects of biological network analysis, a major theme in the area of systems biology. The course addresses protein-protein interaction networks, signaling, and metabolic networks, and covers issues related to reconstructing, analyzing, and integrating various types of networks. Cross-list: BIOC 572, COMP 572.

Long Title: FOUNDATIONS OF BIOTECHNOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hours: 1

Description: Graduate level introduction to a wide range of research methods in biosciences and bioengineering. Individual faculty members from the Biosciences and Bioengineering will each present practices and techniques for their areas of expertise. A web-based methods database will be constructed, with student involvement, from the library of lectures. Cross-list: BIOC 576.

Long Title: FOUNDATIONS OF BIOTECHNOLOGY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 1

Description: Graduate level introduction to a wide range of research methods in biosciences and bioengineering. Individual faculty members from the biosciences and bioengineering will each present practices and techniques for their areas of expertise. A web-based methods database will be constructed, with student involvement, from the library of lectures. Cross-list: BIOC 577.

Long Title: BIOTECHNOLOGY PRACTICUM

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Independent Study

Credit Hours: 1

Description: This course is part of the NIH Biotechnology Training Program and is limited to program participants. Students will receive exposure and training in cutting edge concepts and technologies. Cross-list: BIOC 578.

Long Title: INTRODUCTION TO FUNCTIONAL MAGNETIC RESONANCE IMAGING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hours: 3

Description: A comprehensive introduction to all aspects of functional magnetic resonance imaging, a cutting-edge methodology that allows direct observation of the neural processing underlying human perception and cognition. Lectures will cover methods and applications of fMRI. The lab portion will involve designing experimental paradigms and collecting and analyzing fMRI data. Taught in even years only. Cross-list: PSYC 579.

Long Title: PROTEIN ENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Manipulation of gene expression in prokaryotic and eukaryotic cells. Rational design and directed evolution for cell and protein engineering. Selection and screening technologies and process optimization. Synthetic Biology: engineering and application of gene circuits. Molecular biotechnology applications: Diagnosis, Therapeutics and Vaccines. Cross-list: BIOC 580, CHBE 580. Recommended Prerequisite(s): CHBE 310/510 or equivalent is highly recommended.

Long Title: CARDIOPULMONARY DYNAMICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): ELEC 481 AND ELEC 482 AND ELEC 507

Description: Autonomic nervous system control of the cardiovascular and respiratory systems. Development of a large scale model of the human cardiopulmonary model used to simulate measured data from functional laboratory tests. Includes a study of instrumentation and techniques used in the cardiac catherization laboratory. A discussion of ventricular assist devices is included. The course serves as an introduction to engineering in cardiovascular diagnosis and critical care medicine. Requirements: Knowledge of ordinary differential equations; electricity and magnetism, and solid mechanics from elementary physics; linear control theory and elementary physiology of the cardio vascular and respiratory systems. Repeatable for Credit.

Long Title: TRANSLATIONAL BIOENGINEERING SEMINAR

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Seminar

Credit Hours: 1.5

Description: A seminar series focused on translational research opportunities to be held each semester. Each seminar will be jointly presented by a clinical faculty member, a basic science faculty member, and bioengineering faculty member to integrate focused discussion of clinical cancer needs, advances in cancer biology, and new diagnostic and therapeutic technologies which build on these advances to meet clinical needs. Seminars held at MDACC.

Long Title: OPTICAL IMAGING AND NANOBIOPHOTONICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: This course focuses on diagnostic and therapeutic applications of photonics-based technologies with particular emphasis on nanotechnology enabled optical approaches. This course emphasizes biomedical applications of optics and complements BIOE 484 which introduces fundamental principles of optics to bioengineers. Recommended Co or Prerequisite: BIOE 383.

Long Title: COMPUTATIONAL MOLECULAR BIOENGINEERING/BIOPHYSICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: This is a course designed for students in computationally-oriented biomedical and bioengineering majors to introduce the principles and methods used for the simulations and modeling of macromolecules of biological interest. Protein conformation and dynamics are emphasized. Empirical energy function and molecular dynamics calculations are described. Specific biological problems are discussed to illustrate the methodology. Classic examples such as the cooperative mechanism of hemoglobin and more frontier topics such as the motional properties of molecular motors and ion channels as well as results derived from the current literature are covered. Cross-list: BIOC 589. Recommended prerequisite(s): MATH 212, BIOS 301, BIOE 332.

Long Title: SENSORY NEUROENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Independent Study

Credit Hours: 3

Description: This course will explore how bioengineering techniques and principles are applied to understand and model sensory systems, with a focus on the auditory, vestibular, and visual systems. The interaction between the electrical, mechanical and optical aspects of these systems, and ways to modulate these interactions, will be explored. The course will also cover the design of current auditory, visual and somato-sensory neuroprosthetics (i.e. cochlear- implants, retinal implants and brain-machine interfaces), as well as emerging technologies for neural stimulation. Graduate/Undergraduate Equivalency: BIOE 492. Mutually Exclusive: Cannot register for BIOE 592 if student has credit for BIOE 492.

Long Title: TRAINING IN THE RESPONSIBLE CONDUCT OF RESEARCH

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Lecture

Credit Hours: 1

Description: This course will consider ethical issues involving human and animal subjects, record keeping, publications, potential conflict of interest, and behavior toward colleagues, research fellows, students, and employees. Cross-list: BIOC 594.

Long Title: BIOMEMS AND MEDICAL MICRODEVICES

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Our society is on the cusp of a revolution that will change the practice of medicine. Microfabrication methods that have empowered electronics are now starting to invade areas of biomedical devices. Through this course, students will obtain knowledge of basic element and major classes of molecular sensors, nanodevices, and biomedical Microsystems. NOTE: The graduate version of this course will require more advanced work in the form of exams and presentation than the undergrad version. Cross-list: CHEM 598, Graduate/Undergraduate Equivalency: BIOE 498.

Long Title: METHODS OF MOLECULAR SIMULATION

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): CHBE 611 OR BIOE 589 OR BIOS 589 OR CHEM 520 OR PHYS 526 or permission of instructor

Description: Modern simulation techniques for classical atomistic systems. Review of statistical mechanical systems. Monte Carlo and molecular dynamics simulation techniques. Extensions of the basic methods to various ensembles. Applications to simulations of large molecules such as proteins. Advanced techniques for simulation of complex systems, including constraint satisfaction, cluster moves, biased sampling, and random energy models. Cross-list: PHYS 610.

Long Title: BIOENGINEERING AND CARDIAC SURGERY

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: This course will address biomaterials and medical devices relevant to cardiac and vascular surgery and interventional cardiology in adult and pediatric patients. Mechanical and design considerations, notable successes and failures, and ethical issues will also be discussed, as will differences in cardiac disease and care due to health disparities.

Long Title: TISSUE ENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Study of cell-cell interactions and the role of the extracellular matrix in the structure and function of normal and pathological tissues. Includes strategies to regenerate metabolic organs and repair structural tissues, as well as cell-based therapies to deliver proteins and other therapeutic drugs, with emphasis on issues related to cell and tissue transplantation such as substrate properties, angiogenesis, growth stimulation, cell differentiation, and immunoprotection. Cross-list: CHBE 620.

Long Title: BIOMATERIALS ENGINEERING

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): (CHEM 211 OR CHEM 251) AND (BIOS 201 OR BIOC 201) OR BIOE 370 or permission of instructor

Description: Emphasis will be placed on issues regarding design and synthesis of materials to achieve specific properties and biocompatibility. An overview of significant biomaterials application will be given, including topics such as ophthalmic biomaterials, orthopedic applications, cardiovascular biomaterials, and drug delivery systems. Regulatory issues concerning biomaterials will also be addressed. Graduate/Undergraduate Equivalency: BIOE 431. Mutually Exclusive: Cannot register for BIOE 631 if student has credit for BIOE 431.

Long Title: LIFE SCIENCE ENTREPRENEURSHIP AND THE ROLES OF FOUNDERS AND VENTURE CAPTIAL ON HIGH TECH STARTUP

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 1.5

Description: The major trends and innovations driving the creation of new products in large established companies and venture-capital- backed startup companies are discussed. This pragmatic, experienced-based course describes the venture capital process, formation, and capitalization of high-tech companies, sources of technologies, role of tech transfer at universities and medical schools, startup operational issues, role of VCs and board members, execution time frames, liquidity process, IPOs and mergers, and payout prospects for founders and inventors. Cross-list: MGMT 633. Repeatable for Credit.

Long Title: CELL MECHANICS, MECHANOTRANSDUCTION AND THE CELL MICROENVIRONMENT

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Mechanotransduction is a fundamental process essential for living systems and plays a fundamental role in cell signaling, cancer metastasis and stem cell differentiation. Additionally, fundamental biological processes such as endocytosis cell fusion and cell migration are driven by a coordinated interplay of molecular interactions that drive membrane deformation. This course will survey the current understanding of mechanotransduction and the mechanical properties of cells and their microenvironment, including membrane and cytoskeletal mechanics. Experimental approaches for measuring and manipulating the material properties of cells and their environment; including optical, electrical and magnetic techniques will be covered. A variety of application will be covered, including manipulation in engineering of mechanotransduction pathways to drive cell migration and stem cell differentiation. Instructor Permission Required.Cross-list: BIOC 643, PHYS 643.

Long Title: ADVANCED COMPUTATIONAL MECHANICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Prerequisite(s): BIOE 554 OR CEVE 554 OR MECH 554 OR BIOE 454 OR CEVE 454 OR MECH 454 or permission of instructor

Description: Advanced topics in computational mechanics with emphasis on finite element methods and fluid mechanics. Stabilized formulations. Fluid-particle and fluid-structure interactions and free-surface and two-fluid flows. Interface tracking and interface-capturing techniques, space-time formulations, and mesh update methods. Enhanced discretization and solution techniques. Iterative solution methods, matrix-free computations, and advanced preconditioning techniques. Cross-list: CEVE 654, MECH 654.

Long Title: ONCOLOGY FOR BIOENGINEERS: MOLECULES TO ORGANS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Students will work through a series of patient cases that present foundational oncology concepts for graduate bioengineering and biomedical science students interested in cancer-related translational research. The class will use collaborative problem-based learning to evaluate risk factors, epidemiology, prevention, screening and detection, clinical signs and symptoms, staging and grading, management, and clinical trials for a variety of cancers. Emerging research findings and their clinical and engineering applications will be emphasized. Students will review and collaboratively discuss each case, decide on relevant learning issues, gather information, present findings for further review and discussion, and submit a case-specific written assignment. Using the same model, each student will then develop and lead his/her own patient case for class study. Instructor Permission Required. Required: Admission to Med Into Grad Program.

Long Title: NEW TECHNIQUES FOR CANCER DIAGNOSIS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 1

Description: This course will provide an overview of promising cancer-related biomarkers, and biomarker identification techniques, molecular targeting technologies, sensing and transducing technologies, and imaging technologies. Prerequisites: Admission to BIOE Graduate Program. Instructor Permission Required.

Long Title: SYSTEMS BIOLOGY OF HUMAN DISEASES

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: Introduction to concepts necessary for application of systems - Biology Approaches to Human Diseases. Topics include transcriptional and metabolic design principles, introduction to various regulatory network motifs in diseases and potential treatments using embryonic stem cells. Analysis of complex diseases using engineering concepts such as optimality, nonequilibrium thermodynamics, multiscale analysis and spatiotemporal transport. Cross-list: CHBE 682.

Long Title: ADVANCED BIOPHOTONICS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 3

Description: This advanced topics course focuses on novel technologies for optical spectroscopy, microscopy, and in vivo imaging with an emphasis on applications in clinical medicine. Previous course work in optics is required.

Long Title: PROFESSIONAL DEVELOPMENT FOR BIOENGINEERS

Department: Bioengineering

Grade Mode: Standard Letter

Course Type: Lecture

Credit Hours: 1.5

Description: Professional development topics relevant to academic careers including applying for faculty positions, interviewing , negotiating offers, building a lab, obtaining funding and balancing professional obligations. Designed for graduate students planning academic careers in research-intensive bioengineering departments.

Long Title: GRADUATE SEMINAR

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Seminar

Credit Hours: 1

Description:  Repeatable for Credit.

Long Title: GRADUATE SEMINAR

Department: Bioengineering

Grade Mode: Satisfactory/Unsatisfactory

Course Type: Seminar

Credit Hours: 1

Description:  Repeatable for Credit.

Long Title: VISITING RESEARCH TRAINEE

Department: Bioengineering

Grade Mode: Audit

Course Type: Research

Credit Hours: 0